Endocrine Abstracts

The cytoplasmic domains of EGF-like ligands have important biological functions. Stable transfectants of the human follicular thyroid carcinoma cell line FTC-133 over-expressing the cytoplasmic domain of proEGF (FTC-133-proEGFcyt) demonstrated a transcriptional up-regulation of the lysosomal hydrolases cathepsin- (cath-) B and -D and alterations in the processing of cath-L protein. Cath-L has strong elastinolytic activity and was the only of the three cathepsins to be secreted...